Testosterone Replacement Therapy (TRT) is an effective way to address the symptoms of low testosterone in men. However, TRT can sometimes have negative impacts on fertility, which is a major concern for some men. Two popular treatments to address this concern are Human Chorionic Gonadotropin (HCG) and Clomiphene Citrate (Clomid). While both treatments are effective, they have differences in terms of their effectiveness, safety, and impact on fertility. We will compare HCG and Clomid and suggest which treatment is better for men interested in TRT.
What is Human Chorionic Gonadotropin (HCG)?
HCG is a hormone that is naturally produced in women during pregnancy. In men, HCG can stimulate the production of testosterone and improve fertility. HCG mimics the action of luteinizing hormone (LH), which is responsible for stimulating the testicles to produce testosterone. HCG can be administered via injections or sublingual drops.
What is Clomiphene Citrate (Clomid)?
Clomid is a selective estrogen receptor modulator (SERM) that is used to treat infertility in women. In men, Clomid can stimulate the production of testosterone by blocking the negative feedback loop of estrogen on the hypothalamus and pituitary gland. Clomid is typically administered orally in tablet form.
Comparing HCG and Clomid
HCG v Clomid: Effectiveness
HCG is a more potent stimulator of testosterone production than Clomid. HCG can directly stimulate Leydig cells in the testes to produce testosterone, while Clomid indirectly stimulates testosterone production by blocking the negative feedback loop of estrogen on the hypothalamus and pituitary gland. In one study, men who were treated with HCG showed a significantly greater increase in testosterone levels compared to men who were treated with Clomid.
HCG v Clomid: Safety and side effects
Both HCG and Clomid are generally safe for most men. However, HCG can cause some side effects, including acne, mood swings, and enlargement of the prostate. I Clomid can cause some side effects, including hot flashes, mood swings, and headaches. In rare cases, Clomid can also cause vision problems, which typically resolve once treatment is discontinued.
HCG v Clomid: Impact on Fertility
Both HCG and Clomid can improve fertility in men who are undergoing TRT. HCG can directly stimulate the testes to produce testosterone and increase sperm production. Clomid can indirectly stimulate testosterone production and increase sperm production by blocking the negative feedback loop of estrogen on the hypothalamus and pituitary gland. However, HCG may be a better option for men who are concerned about fertility as it directly stimulates the testes to produce testosterone and may lead to a faster recovery of sperm production.
Combining HCG or Clomid with Testosterone Therapy
Both HCG and Clomid can be used in combination with testosterone therapy to maintain fertility. HCG is typically used in conjunction with testosterone therapy to prevent testicular atrophy and maintain sperm production. Clomid can also be used in conjunction with testosterone therapy to prevent testicular atrophy and maintain sperm production. However, Clomid may be less effective than HCG at preventing testicular atrophy.
Conclusion: Is HCG better than Clomid?
HCG and Clomid are both effective treatments for maintaining fertility in men who are undergoing TRT. HCG is a more potent stimulator of testosterone production and may be a better option for men who are concerned about fertility and testicular atrophy.
March 25th, 2023
Posted In: Low T Info
Clomid, fertility, free t, HCG, Human Chorionic Gonadotropin, low t, motility, shrinkage, sperm, sperm count, testicles, testicular atrophy, testosterone
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Many guys find testosterone injection intimidating, perhaps because there isn’t enough information about it to get started. Men ask for complete details and for that, below is a brief discussion on what you need to know about TRT when getting started.
Testosterone Injection Protocol
- 1.0 mg Arimidex (Anastrozole) per week in divided doses
- 250 IU Human Chorionic Gonadotropic injected subcutaneously every other day
- 100 mg testosterone enanthate or cypionate given per week, could be two or more depending on doctor’s advise
Testosterone injection done once a week causes spikes in the level of testosterone followed by lows. This can make you feel worse by the end of the end compared to your pre-TRT stare. Later on, the dead zone gets broader, feeling no relief with testosterone injection. This makes injecting twice a week or every other day (EOD) much better.
When you have frequent injections, the volumes are too small, using #29 0.5ml 50IU insulin syringes. You can inject in the muscle at the side of your thighs (vastus lateralis). The injection loads very slowly, however, the tiny plunger causes very high pressures. Never use 1.0ml syringes. The same size of syringe can be used for HCG injections.
Small needles cause less muscle damage. Some use #25 needle but this may not be faster compared to 50IU insulin needles. A clinical research has found that testosterone injection through subcutaneous tissue, which is under the skin into the body fat, provide a steadier levels of testosterone and enhances sense of well-being.
For men who exercise, sweat or shower a lot, transdermal testosterone gels and creams are not advised. Transdermal creams and patches are quite hefty and about 10 percent only of its testosterone content is absorbed. Also, men who have low levels of thyroid hormones don’t efficiently absorb testosterone administered topically.
Some people absorbs transdermal creams at the beginning, however, changes in the skin can prevent absorption after some time. With testosterone injections. There are no uncertainties or limitations when it comes to delivery of the drug.
Guidelines on hCG Injection
Human Chorionic Gonadotropin (hCG) is a water-based peptide hormone that is injected to replenish lost luteinizing hormone (LH) that TRT suppresses. A lack of hCG can result to deactivation of LH receptors present in the testes. This results in:
- Shrinkage of testes. For some, the testes can eventually lead to testicular atrophy. The degree of shrinking differs from person to person, but is more common among older men.
- Fertility can be greatly affected. If you want an offspring, hCG injection is necessary. If not given, it may greatly reduce fertility or you may not recover fertility.
- Less pain sensation. When the testes shrinks, some men feel pain in their testes. You can avoid this situation by injecting hCG.
- When there’s a huge dearth of hCG and LH, the scrotum shrinks too and pull up to the body, giving the pre-pubescent appearance. This isn’t good for a person’s body image perception, and may also affect how women see you sexually.
- Promotes pregnenolone production. Testes are the major producer of the hormone pregnenolone – a precursor to all steroid hormones such as cortisol, testosterone, DHEA, estrogen among other. It is also vital for proper mental functioning. hCG injection prevents a drug-induced deficiency of pregnenolone. People who are on TRT without hCG and then just start hCG reported a significant improvement on their mood, that most attributed to increase in pregnenolone levels.
When you inject hCG, you administer it into the fat beneath the skin the same as diabetics administer insulin. Research on the use of subcutaneous injection in men has showed the effectiveness of 250IU EOD dose. You can look for diabetes patient education material on how to administer insulin injection to be used for testosterone injection or hCG.
Guidelines on Anastrazole and Aromotase Inhibitors
Elevated serum estradiol/E2 (30pg/ml and above) can interfere many benefits of testosterone injection. A serum estradiol equivalent to 22pg/ml is near optimal and to be able to get near this level, a person should take Anastrozole. Many men who began with TRT experienced favourable results that later on faded as estrogen levels increase.
My advice is to begin Anastrozole at 1.0mg per week in divided doses beginning at the day of your first injection. Then follow up estrogen lab tests for any necessary Anastrozole dose adjustments. It is not a good idea to wait and check if your estrogen levels increase before taking action. Take Anastrozole EOD if possible.
Testosterone injection with a dose of 100mg should result in 800 to 900 total testosterone (TT) range. While this is a good result, monitor your free testosterone (FT) or the bio-available testosterone. Some doctors won’t bother looking at the TT numbers at all. With age, SHBG (Sex hormone-binding globulin) levels increase while FT levels decrease.
See, a TT of 1000 of a young man won’t be the same as the TT of 1000 for an older man with high SHBG levels, because the FT level of the older man will likewise be well below, even though they have the same TT. Lab ranges presented on lab reports are age-adjusted.
Further, you have to know about prostate-specific antigen (PSA), problems in the prostate and digital rectal exam. Estrogen is a major factor of enlarged prostate or BPH (Benign prostatic hyperplasia). Many find that decreasing estrogen to 22pg/ml improves their urine flow as well as BPH. You also have to monitor your haematocrit levels as part of routine lab work.
Hormone Therapeutics Testosterone Therapy
Being a leading provider of low testosterone therapy solutions, we are always looking for newer ways to improve blood testosterone levels for our patients. We believe on improving testosterone levels with not only different testosterone treatment options that we offer, but also with diet, exercise, and therapeutic methods. Over the years, we have seen that our patients have greatly benefited from our Low-T therapy and treatment solutions, and our network of patients have grown across across all major cities of United States, including: Los Angeles, Houston, Miami, Chicago, Jersey City, and Seattle.
If you or a loved one is dealing with low blood testosterone levels, contact us today to get a free evaluation of your Low-T symptoms and see how our treatment options can help you with your low testosterone.
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January 17th, 2017
Posted In: Testosterone Therapy
anastrozole, aromatase inhibitors, free testosterone, HCG, Human Chorionic Gonadotropin, LH, Luteinizing Hormone, pregnenolone, prostate-specific antigen, serum estradiol, testicular atrophy, testosterone, Testosterone Enanthate, testosterone injection, Total Testosterone, TRT, TRT protocol
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