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human growth hormoneSermorelin, medically termed as growth hormone releasing factor 1–29 NH2-acetate, is a bio-identical human growth hormone that has been genetically engineered to trigger the production of growth hormone releasing hormone (GHRH) coming from the hypothalamus, a gland next to the pituitary gland.

GHRH is a type of peptide containing 29 amino acids present on our own growth hormone. These amino acids are the active ones of GHRH. GHRH stimulates the pituitary gland to release growth hormones. As we age, the hormones secreted by the pituitary gland become depleted. Studies have shown the Sermorelin can restore the growth hormone to a youthful level by elevating the levels of IGF-1 (Insulin-like Growth Factor 1).

What are the Benefits of Sermorelin?

Sermorelin offers a handful of benefits. Patients can expect to notice:

  • Increase in their energy level due to fat breakdown
  • Increase in lean muscle due to efficient protein synthesis
  • Increase in muscles mass
  • Reduction in body fat due to efficient fat burning or lipolysis
  • Stronger joints and connective tissue
  • Stronger immune system
  • Increase in bone density due to increase in calcium retention
  • Improved cognitive performance
  • Efficient function of all internal organs

How does Sermorelin look like?

Sermorelin comes in an injectable vial, often in multi-dosage. Each vial contains 15 mg of lyophilized Sermorelin acetate. It is vacuum sealed to protect and preserve the hormone peptide. Every vital also comes with a diluent – a bottle of Bacteriostatic water.

How does Sermorelin administered?

Sermorelin is administered via subcutaneous injection using a fine needle similar to the one used for insulin among diabetics. The frequency is usually daily and is reduced over time.

When should I take Sermorelin?

The best time to administer Sermorelin is before bedtime. Growth hormone is usually released while asleep. During this time, it is highly beneficial for the body’s repair and recovery. Sermorelin has also a sleep-promoting effect and so, it can make you feel sleepy if administered during the day.

How will I know if Sermorelin is taking effect?

Both IGF-1 and HGH are secreted in a pulsatile nature, rather than constant. As such, a random blood analysis isn’t enough to achieve precise measurement. Physicians who prescribe Sermorelin and other similar peptides determine the effectiveness of the medication through symptomology or the study of the symptoms to check the benefits, blood analysis and physical appearance.

You’ll notice that it’s working if you experienced an improved sleep after several weeks of therapy. But this can only be noticed by those who have difficulty sleeping, however, most patients reported an improvement in sleep quality. It is usually accompanied with an improved mood and increase in energy level.

After 3 to 6 months of therapy, patient start to report significant changes in the body such as a leaner physique and increase in muscle mass. Later on, they will also notice a huge improvement in their overall health.

How long does Sermorelin take to work?

Similar to most human growth hormone medications, Sermorelin often has a ‘loading’ period between 3 and 6 months before you notice the full effects. When injected, Sermorelin is eliminated from the system rapidly and must be injected frequently. Its mechanism of action relies on a chain reaction of biological processes that result in increased growth factors and HGH. It will take some time for the levels to be optimal and achieve the benefits.

Do I have to take Sermorelin for the rest of my life to maintain the positive results?

The answer is no. Sermorelin has an active sustaining effect where the optical HGH level keeps after the last injection. Similar to synthetic HGH, Sermorelin should be injected daily but once the optimal levels are achieved, the frequencies of the injection can be reduced or stopped. When the results are achieved, the patient can shift to a maintenance protocol where the need for daily injections is eliminated.

Sermorelin vs. Synthetic Human Growth Hormone

Sermorelin is Better in Reducing Body Fat

Lipodystrophy is a condition characterized by abnormal accumulation of adipose tissue or body fat in certain areas of the body, usually at the legs, stomach, lower back and hips. Lipodystrophy is similar to the increase of body fat occurring as we age. A study on the effects of GHRH on HIV-positive men experiencing lipodystrophy has been published in 2011.

Results of the study showed that patients given with GHRH lost body fat and increased muscle mass, which significantly improved total body composition. The study concluded that GHRH was well tolerated by the patients and effectively increase IGF-1 level in HIV patients with lipodystrophy. The use of Sermorelin may potentially be beneficial for this population.

In Santa Monica, Ca, Dr. Rand McClain has found that patients experienced marked adipose tissue loss upon using Sermorelin. Many athletes have used Sermorelin and other peptides to reduce body fat and increase lean muscle. Additionally, Sermorelin plays a huge role in exercise recovery.

The Use of Synthetic Human Growth Hormone May Decrease Lifespan

Patients taking human growth hormone may actually shorten your lifespan, which totally conflicting to how it’s supposed to promote – anti-aging. Synthetic HGH is believed to bypass the pituitary axis going straight to the liver. This results to an increase of IGF-1 for an extended period of time. Persistent elevation of IGF-1 is harmful to health, and may lead to disease.

Many credit the beneficial effects of HGH to the mechanism of IGF-1 but this isn’t true. Studies revealed that the ideal environment for promoting positive health and enhancing longevity is to have high levels of naturally-produced growth hormone as well as growth hormone reserves and pulsing IGF-1. A pulsing IGF-1 means that the level fluctuates throughout the day with levels having high peaks and low valleys. Because IGF-1 is a highly powerful factor, it is so important that the level is maintained at all times, using only IGF-1 when necessary. Additionally, it was recently discovered in a clinical observation that some effects falsely associated to IGF-1 such as gain of lean muscle and extreme fat loss are actually the result of increase in endogenous growth hormone and not the IGF-1.

The use of Sermorelin acetate promote longevity by increasing the production of human growth hormone and promoting pituitary reserves of HGH. Sermorelin doesn’t bypass the pituitary-GH axis and as such, providing better control of IGF-1 level to preserve health.

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