Sermorelin, medically termed as growth hormone releasing factor 1–29 NH2-acetate, is a bio-identical human growth hormone that has been genetically engineered to trigger the production of growth hormone releasing hormone (GHRH) coming from the hypothalamus, a gland next to the pituitary gland.
GHRH is a type of peptide containing 29 amino acids present on our own growth hormone. These amino acids are the active ones of GHRH. GHRH stimulates the pituitary gland to release growth hormones. As we age, the hormones secreted by the pituitary gland become depleted. Studies have shown the Sermorelin can restore the growth hormone to a youthful level by elevating the levels of IGF-1 (Insulin-like Growth Factor 1).
Sermorelin offers a handful of benefits. Patients can expect to notice:
Sermorelin comes in an injectable vial, often in multi-dosage. Each vial contains 15 mg of lyophilized Sermorelin acetate. It is vacuum sealed to protect and preserve the hormone peptide. Every vital also comes with a diluent – a bottle of Bacteriostatic water.
Sermorelin is administered via subcutaneous injection using a fine needle similar to the one used for insulin among diabetics. The frequency is usually daily and is reduced over time.
The best time to administer Sermorelin is before bedtime. Growth hormone is usually released while asleep. During this time, it is highly beneficial for the body’s repair and recovery. Sermorelin has also a sleep-promoting effect and so, it can make you feel sleepy if administered during the day.
Both IGF-1 and HGH are secreted in a pulsatile nature, rather than constant. As such, a random blood analysis isn’t enough to achieve precise measurement. Physicians who prescribe Sermorelin and other similar peptides determine the effectiveness of the medication through symptomology or the study of the symptoms to check the benefits, blood analysis and physical appearance.
You’ll notice that it’s working if you experienced an improved sleep after several weeks of therapy. But this can only be noticed by those who have difficulty sleeping, however, most patients reported an improvement in sleep quality. It is usually accompanied with an improved mood and increase in energy level.
After 3 to 6 months of therapy, patient start to report significant changes in the body such as a leaner physique and increase in muscle mass. Later on, they will also notice a huge improvement in their overall health.
Similar to most human growth hormone medications, Sermorelin often has a ‘loading’ period between 3 and 6 months before you notice the full effects. When injected, Sermorelin is eliminated from the system rapidly and must be injected frequently. Its mechanism of action relies on a chain reaction of biological processes that result in increased growth factors and HGH. It will take some time for the levels to be optimal and achieve the benefits.
The answer is no. Sermorelin has an active sustaining effect where the optical HGH level keeps after the last injection. Similar to synthetic HGH, Sermorelin should be injected daily but once the optimal levels are achieved, the frequencies of the injection can be reduced or stopped. When the results are achieved, the patient can shift to a maintenance protocol where the need for daily injections is eliminated.
Lipodystrophy is a condition characterized by abnormal accumulation of adipose tissue or body fat in certain areas of the body, usually at the legs, stomach, lower back and hips. Lipodystrophy is similar to the increase of body fat occurring as we age. A study on the effects of GHRH on HIV-positive men experiencing lipodystrophy has been published in 2011.
Results of the study showed that patients given with GHRH lost body fat and increased muscle mass, which significantly improved total body composition. The study concluded that GHRH was well tolerated by the patients and effectively increase IGF-1 level in HIV patients with lipodystrophy. The use of Sermorelin may potentially be beneficial for this population.
In Santa Monica, Ca, Dr. Rand McClain has found that patients experienced marked adipose tissue loss upon using Sermorelin. Many athletes have used Sermorelin and other peptides to reduce body fat and increase lean muscle. Additionally, Sermorelin plays a huge role in exercise recovery.
Patients taking human growth hormone may actually shorten your lifespan, which totally conflicting to how it’s supposed to promote – anti-aging. Synthetic HGH is believed to bypass the pituitary axis going straight to the liver. This results to an increase of IGF-1 for an extended period of time. Persistent elevation of IGF-1 is harmful to health, and may lead to disease.
Many credit the beneficial effects of HGH to the mechanism of IGF-1 but this isn’t true. Studies revealed that the ideal environment for promoting positive health and enhancing longevity is to have high levels of naturally-produced growth hormone as well as growth hormone reserves and pulsing IGF-1. A pulsing IGF-1 means that the level fluctuates throughout the day with levels having high peaks and low valleys. Because IGF-1 is a highly powerful factor, it is so important that the level is maintained at all times, using only IGF-1 when necessary. Additionally, it was recently discovered in a clinical observation that some effects falsely associated to IGF-1 such as gain of lean muscle and extreme fat loss are actually the result of increase in endogenous growth hormone and not the IGF-1.
The use of Sermorelin acetate promote longevity by increasing the production of human growth hormone and promoting pituitary reserves of HGH. Sermorelin doesn’t bypass the pituitary-GH axis and as such, providing better control of IGF-1 level to preserve health.
Being a leading provider of low testosterone therapy solutions, we are always looking for newer ways to improve blood testosterone levels for our patients. We believe on improving testosterone levels with not only different testosterone treatment options that we offer, but also with diet, exercise, and therapeutic methods. Over the years, we have seen that our patients have greatly benefited from our Low-T therapy and treatment solutions, and our network of patients have grown across across all major cities of United States, including: Los Angeles, Houston, Miami, Chicago, Jersey City, and Seattle.
If you or a loved one is dealing with low blood testosterone levels, contact us today to get a free evaluation of your Low-T symptoms and see how our treatment options can help you with your low testosterone.
Saleamp Design January 6th, 2017
Posted In: Testosterone Therapy
We all age. It is inevitable. It is part of life. Sermorelin can help.
Yet most of us wish to keep a highest quality of life as we age – a life where we can still keep as much of the strength, energy and appearance that we enjoy in our youth. Likewise, we hope to be spared the damage that comes with degenerative diseases. Hormones highly affects our vitality and longevity – an important key to our ability to look and feel young.
As we age, hormone levels change and evolve. The energy-producing, fat-burning hormones fall while the energy-depleting, fat-storing hormones will inversely rise. Such changes makes us feel and look older.
Sometimes, hormones severely drops into a deficiency, below the level that can maintain the best health outcomes. In this situation, hormone optimization– through exercise, sleep, diet, lifestyle changes and hormone therapy – can be very beneficial to one.
Human growth hormone is one of the most common, and important, body hormones that usually drops to deficiency level.
Adult growth hormone deficiency (AGHD) is being recognized increasingly. It has been associated with cardiovascular, metabolic, neuromuscular, neuropsychiatric-cognitive and skeletal abnormalities.
Most of these symptoms can be reversed through growth hormone therapy. Adult Growth Hormone Deficiency must be diagnosed before a physician can legally prescribe HGH to a patient.
Sermorelin Acetate (GRF 1-29) is a bio-identical growth hormone-releasing hormone that can be used to safely stimulate the production of growth hormone from the pituitary gland. An FDA-approved medication, it has been genetically engineered to increase the levels of growth hormone and reverse the effects of AGHD.
Sermorelin acetate was first developed in the 1970s, and was considered to be the shortest, yet fully functional piece of GHRH, that has been used to test for human growth hormone secretion.
Sermorelin has been used as a hormone replacement therapy for testosterone in men and an anti-aging product. Unlike human growth hormone, Sermorelin is a secretagogue, which means it stimulate the gland to secrete hormone.
The effect of growth hormone-releasing hormone is better observed among patients who secrete little to zero growth hormone due to pituitary tumors or the total removal of the gland where human growth hormone is produced.
Regardless of the age, all patients manifest similar psychological effects due to growth hormone deficiency. Symptoms include mood swings, anxiety, increased social isolation, decreased work capacity and depression (Ronald Klatz, Robert Goldman, Stopping the Clock, 2003).
GHRH has also been found to have positive effect on patients with mild cognitive impairment. In a study by the University of Washington School of Medicine (2013), thirty adults (17 diagnosed with mild cognitive impairment) ranging in age between 55 and 87 years participated in a study on the neurochemical effects of GHRH.
After 20 weeks of GHRH administration, results showed an increase in gamma-Aminobutyric acid (GABA) and N-acetylaspartylglutamate (NAAG), and a decrease in myo-inositol (MI), which are positive indicators that may help reverse age-related decline and improve cognitive function.
Do You Need Help?
Hormone Therapeutics is the leading national company assisting men who want to get their lives back through Hormone Replacement and Testosterone Replacement therapy. Our local physicians are ready to treat you anywhere in the entire country. Hormone Therapeutics is pioneering an easier, cost efficient and more private way for you to work with our clinical advisors and physicians from the privacy of your home or office after your local physical exam confirms you have one of the symptoms of Low T.
Contact us today and our clinical advisors will work with you on a hormone therapy program that may include prescribed hormones, exercise, nutrition and sleep programs to reclaim your vitality.
Saleamp Design March 20th, 2016
Posted In: Health & Wellness
Tags: anti-aging product, brain function, cognitive skills, depression, fatigue, GHRH, growth hormone therapy, growth hormone-releasing hormone, HGH, hormone replacement therapy, hormone therapy, human growth hormone, memory, Sermorelin