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From Intramuscular Testosterone to Subcutaneous Testosterone Injections

testosterone injectionsThe most common types of testosterone injections are oil-based injectables administered to patients once or twice a week. Popular testosterone supplements, testosterone cypionate, propionate and enanthate have traditionally been injected through Intramuscular means as this was previously seen as the only possible method for providing patients with the testosterone esters. To administer these Intramuscular injections, patients are usually injected with needles measuring 1 inch to 1.5 inches, into the glute or hip, once a week.

However, recent studies have provided a different angle to this practice, saying that administration of these esters does not have to be limited to Intramuscular means. Over the years, there have been multiple studies exploring the possibility of other alternatives to Intramuscular administration. As a result, newer researches have debunked the common perception that Intramuscular administration is the only effective way to inject testosterone, strengthening the case for subcutaneous injections as a means of administering the esters.  Additionally, physicians are also exploring the possibility that subcutaneous injections may address common problems encountered with Intramuscular administration of testosterone.

Subcutaneous injections and less testosterone fluctuations

A common problem encountered with intramuscularly administered testosterone esters is their tendency to cause fluctuating hormone levels.

Intramuscular injections are typically administered weekly.  The patients testosterone levels peak in the first day and then are back to normal levels by day 6 or 7.  If a physician is prescribing monthly or bi-monthly injections the trough the patient develops after a week while waiting for the next injection will send that patient on a roller coaster.   As result, some patients experience a spike in their testosterone levels, where the testosterone serum in their system reaches high doses the following period after injections.

Testosterone Leveling

The peak from the injection comes to an end after several days. Once the hormones are metabolized, what is left is a gradual decrease of the testosterone in the system. Because of this, some patients experience a “peak and trough” fluctuation in hormone levels, resulting in uneven presence of testosterone.

Subcutaneous administration of testosterone serums are being explored as a possible remedy to this issue. A pilot study researching the effects of subcutaneous testosterone injections on hypogonadal males has shown that a smaller, more frequent dose of the serum levels showed peak and trough levels within the normal range for 100% of the patients.

 As an alternative option that can replace Intramuscular injection’s weekly doses of the serum, a subcutaneous injection can be divided into two smaller doses each week. This practice levels the amount of testosterone serum in a patient, preventing large spikes and decreases experienced from intramuscular injection. This results in a more balanced and stable presence of the hormone in the patient.

Subcutaneous Testosterone Injections are Easier

Subcutaneous injections make testosterone administration more convenient for patients

Increased studies showing the viability of subcutaneous hormone administration bring many possibilities for patients going through testosterone treatments.

Aside from providing a more balanced testosterone concentration and more level peaks and troughs, subcutaneous injections are generally seen as more convenient for the patient. As an alternative to intramuscular injections, subcutaneous administration provides a cheap and less painful means of administering hormones.

Because of this, more providers, scientists and companies are exploring options that employ subcutaneously administered testosterone.

Hormone Therapeutics provides you the right method for you

As men age, testosterone concentration decline, causing many symptoms of low testosterone and unsatisfactory changes or difficulties in their lives. However, thanks to increasing medical advancements, these hormonal deficiencies and issues are no longer problems men have to bear on their own.

With the increasing amount of alternatives for testosterone treatment nowadays, it is not difficult for men to find a treatment method that they are comfortable with. As a variety of hormone treatments to supplement endocrine systems are now being made available, men can now choose to improve their quality of life through treatment methods that are best suited for them.

Here at Hormone Therapeutics, we want to help you find the best alternative for you so you can live better. Focused on making sure that each client gets a convenient and affordable solution to their needs, we provide testosterone injections, along with various endocrine treatments in order to improve quality of life.  All our articles have been brought to you by SEO Advisors.

If you have any questions or inquiries regarding subcutaneous testosterone injections or other forms of testosterone or hormone therapy, Hormone Therapeutics will be glad to tell you more about our services and provide a physician evaluation of your options. Give us a call and we will help you learn more about testosterone and hormone therapy and find the best solution for you. 

Revealed: Subcutaneous Testosterone Injections Offer More Favorable Effects

Saleamp Design April 19th, 2016

Posted In: Testosterone Therapy

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  • Devin says:

    If a person switches from intramuscular to subcutaneous injections won’t there be a drop in testosterone levels for a while because of the slower absorption rate injecting into the fat?

    • Saleamp Design says:

      The drop would be so quick and could be offset with a loading dose if needed, but patients typically do not feel that drop. Also, the SQ injection is followed by a second injection in 3.5 days, rather than 7 days later to combat those concerns and then the range of high to low narrows on a consistently positive basis.

  • Alexander says:

    The reason of this is of course because it easier to balance testosterone levels when injecting sub Q, you get a more linear and even absorption.

  • Johan says:

    Which testosterone is best used for sub q?
    Regards Johan

    • Saleamp Design says:

      We typically start patients on Testosterone Cypionate in sesame oil, however, this is not always the best option for all patients. We also use Testosterone Propionate and Testosterone Enanthate and alter the suspension oils by patient. We use a combination of self evaluation tools to monitor how you are ‘feeling’ and how your body is reacting that we correlate with your blood tests and alter your treatment accordingly.

    • Saleamp Design says:

      Most patients start of Testosterone Cypionate in grapeseed oil, but then we work with the patients to make sure that treatment agrees best with each individual. We have a series of self evaluation we ask of our patients that we correlate to quantitative test results and find the right solution for each.

  • Vinny Miletti says:

    so what is the difference in the rate of absorption for IM injections versus subcutaneous injections? i.e. 3 hours for IM injection to be absorbed into the system, versus 7 hours for subc, etc. To me, that would be the critical question.

  • Dennis says:

    I have heard that the testosterone gets destroyed in the fat and becomes less effective. is this true.

    • Mike Bellerose says:

      I switched from injections in the mussel to subcutaneously (phamisest and Doctor discussed ) question is, how long does the needle penetrate the skin as it no longer goes into muscle?

      • Saleamp Design says:

        We use 1/2″ syringes for subq. We see positive results with injections into the subcutaneous belly fat layer as well as shallow intra muscular injections into the upper/outer thigh and delt.

  • Toni Holmes says:

    Is testosterone cypionate by pfizer suitable for subq i jection. Im concerned about the suspension it is in

  • Noe Perez says:

    Any other folks have any experience with Sub q injecting. I just started sub q injecting and wanting to know how long it takes to start feeling the effects. I’m on my 2nd injection and developed a painful lump from it.

    • Saleamp Design says:

      We get better self eval scores form patients for the Subq v. IM. You do not peak as high in the first 36 hours or go down as low by day 7 so you have more day to day consistency. The higher the inital peak increases your hematocrit and estradiol increase risks as well. You might not feel as much of an initial rush though since your injection amount is lower. If you are getting a painful lump in the belly, try injecting in the back of the arm or outer/upper thigh. We also believe subq injections bacn be shallow IM injections with the smaller, thinner needles into the thigh or delt.

  • Al says:

    What are your feelings about daily as injections? I realize it may be more inconvenient but I would think it would better mimic your bodies cycle. Thanks

    • Saleamp Design says:

      We see phenomenal results in twice weekly injections with excellent self eval scores. We have a few patients injecting every two days and it fits their needs better. There is a case to be made for daily injection but very few patients would ever notice the difference.

  • David says:

    Why does my doctor prescribe it once a month, when everybody says I should break it down to once a week?

    • Saleamp Design says:

      Your physician is unlikely to be trained on TRT management as the half life of the testosterone in your body is closer to a week than a month. We suspect you feel good for most of that first week and then in weeks 2-4 feel worse than you would if you were not on any program at all. He might not want to inject you every week either due to his schedule. We actually have more than half of our patients injecting two times per week. They receive smaller doses and we keep them at a more consistent T level. It also puts them at lower risks of estradiol conversion or hematocrit increases because we do not spike their levels in those first 36 hours as high as many with less frequent and higher dosages.

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