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testosterone therapyIn a major new study published in the New England Journal of Medicine, testosterone therapy was found to improve physical ability and mood as well as sexual function. The study was a collaboration of researchers from 12 medical centers spanning the United States.

Mark E. Molitch, MD, an endocrinologist, was one of the authors of the study. Dr. Molitch is the Martha Leland Sherwin professor in medicine-endocrinology at the Northwestern University Feinberg School of Medicine.

“In recent years, talk about low testosterone and its treatments have become part of the public discussion,” explained Molitch. “Yet questions have always lingered about the treatment’s effectiveness and safety. I believe the results of this large, nationwide study will provide doctors and patients answers and guidance they’ve been looking for.”

Link between Testosterone, Mood, Libido and Physical Health

The team’s purpose was to determine the link, if any, between testosterone levels and the mood, libido, and physical ability of men over the age of 65. It is a well-established fact that a man’s testosterone levels and production decrease as he ages. Many men also experience lowered sex drive and energy levels as they become older, tiring and fatiguing more easily. For the first time, low testosterone has been established as the cause of these symptoms.

Testosterone Therapy Study Grant

Previously, the Institute for Men reported that there was insufficient evidence of testosterone therapy’s beneficial effects, if any. A grant from the National Institute on Aging and National Institutes of Health funded the new study to determine low testosterone could be the cause of what many consider the normal effects of aging.

Health Study on Testosterone Therapy

The subjects of the study were 790 men, all of whom were over the age of 65 and tested for low blood testosterone, as well as suffering from decreased sexual desire and physical function. Some participants in the study were given testosterone treatments in the form of a gel to apply directly to the skin. The medication increased the subjects’ testosterone levels to the normal range for men aged 19-40. The treatments and study of their effects lasted for over a year.

The study participants who received the testosterone treatments did not report increased energy, but their mood, libido, and physical function did improve. By measuring the distance walked in six minutes, the researchers were able to determine a small increase in the physical abilities of men in the study. There was also a decrease in symptoms of depression, such as feelings of sadness and listlessness.

“Men in the study experienced an increased sexual desire and small improvements in their mood and physical function,” explained Molitch. “Importantly, there was no evidence of an increase in heart or other cardiovascular issues in those who received testosterone compared to a placebo. And we monitored the men in this study for at least a year after receiving treatment.”

The study is expected to lead to further research in the potential applications of testosterone therapy in treating many of the problems that come with age. By firmly showing the link between low testosterone and decreased sexual activity, mood, and physical capabilities, the door is open to developing treatments for these common ailments.

 

Revealed: Testosterone Therapy May Enhance Sexual Drive and Energy Levels

Saleamp Design April 26th, 2016

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male depression and testosteroneMale depression is not as well understood as female hormonal depression.  The effect of female sex hormones on our mood and psyche has been well-documented. Phenomena such as post-partum depression and mood swings just prior to menstruation are well-known, and there have been a number of scientific studies confirming them.

Until recently, though, the link between our mood and the male sex hormone testosterone has not been nearly as well understood. A study conducted by researchers at MedUni Vienna and published in Biological Psychiatry offers the first glimpse into how testosterone affects our mood.

Testosterone and Male Depression

In a nutshell, the study concluded that there is a direct link between testosterone levels and feelings of happiness. Testosterone also supports existing antidepressant medications, allowing them to work better.

As they age, men typically become more prone to depression. Conventional wisdom has been that the drop-off in testosterone production is to blame, but the new study is the first to show that testosterone actually increases the number of serotonin transporters in the brain.

How Serotonin levels Contribute to Male Depression

Serotonin is the neurotransmitter, or brain chemical, most responsible for feelings of well-being and happiness. Serotonin transporters are proteins that help regulate the concentration of serotonin in our brains. By increasing their number, the overall serotonin levels in our brains also increase, contributing to our emotional well-being.

Antidepressant drugs bind to these proteins, as well. By increasing production of serotonin transporters, testosterone creates a better environment for these medications, allowing them to more effectively treat male depression.

The MedUni Vienna researchers worked with transsexuals undergoing hormone therapy in the course of their study. Georg Kranz, the study’s primary author, explained the design of the study.

“Transsexuals are people who feel that they are living in the wrong body and who therefore want high doses of opposite gender hormone therapy to adapt their appearance to that of the other gender. Genetic women are given testosterone, while genetic men are given oestradiol and medications to suppress testosterone production.”

Testosterone and Antidepressants

Siegfried Kasper, head of the Department of Psychiatry and Psychotherapy at MedUni Vienna, elaborated further on their findings and results.

“The study has shown that testosterone increases the potential binding sites for commonly prescribed antidepressants such as SSRIs in the brain and therefore provides major insights into how sex hormones affect the human brain and gender differences in psychiatric illnesses.”

Employing positron emission tomography (PET), the researchers were able to measure serotonin transporter levels in the study participants. Four weeks of testosterone therapy resulted in significantly higher serotonin transporter levels. The study established a firm link between testosterone levels in the blood and serotonin transporter levels in the brain.

The study opens up potential applications for testosterone therapy in treating male depression and other emotional disorders. Testosterone improves our mood both directly and by supporting antidepressant medications, and the reverse is also true. Low levels of testosterone can lead to male depression and feelings of sadness.

 

 

Testosterone Therapy Found to Ease Male Depression

Saleamp Design April 22nd, 2016

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From Intramuscular Testosterone to Subcutaneous Testosterone Injections

testosterone injectionsThe most common types of testosterone injections are oil-based injectables administered to patients once or twice a week. Popular testosterone supplements, testosterone cypionate, propionate and enanthate have traditionally been injected through Intramuscular means as this was previously seen as the only possible method for providing patients with the testosterone esters. To administer these Intramuscular injections, patients are usually injected with needles measuring 1 inch to 1.5 inches, into the glute or hip, once a week.

However, recent studies have provided a different angle to this practice, saying that administration of these esters does not have to be limited to Intramuscular means. Over the years, there have been multiple studies exploring the possibility of other alternatives to Intramuscular administration. As a result, newer researches have debunked the common perception that Intramuscular administration is the only effective way to inject testosterone, strengthening the case for subcutaneous injections as a means of administering the esters.  Additionally, physicians are also exploring the possibility that subcutaneous injections may address common problems encountered with Intramuscular administration of testosterone.

Subcutaneous injections and less testosterone fluctuations

A common problem encountered with intramuscularly administered testosterone esters is their tendency to cause fluctuating hormone levels.

Intramuscular injections are typically administered weekly.  The patients testosterone levels peak in the first day and then are back to normal levels by day 6 or 7.  If a physician is prescribing monthly or bi-monthly injections the trough the patient develops after a week while waiting for the next injection will send that patient on a roller coaster.   As result, some patients experience a spike in their testosterone levels, where the testosterone serum in their system reaches high doses the following period after injections.

Testosterone Leveling

The peak from the injection comes to an end after several days. Once the hormones are metabolized, what is left is a gradual decrease of the testosterone in the system. Because of this, some patients experience a “peak and trough” fluctuation in hormone levels, resulting in uneven presence of testosterone.

Subcutaneous administration of testosterone serums are being explored as a possible remedy to this issue. A pilot study researching the effects of subcutaneous testosterone injections on hypogonadal males has shown that a smaller, more frequent dose of the serum levels showed peak and trough levels within the normal range for 100% of the patients.

 As an alternative option that can replace Intramuscular injection’s weekly doses of the serum, a subcutaneous injection can be divided into two smaller doses each week. This practice levels the amount of testosterone serum in a patient, preventing large spikes and decreases experienced from intramuscular injection. This results in a more balanced and stable presence of the hormone in the patient.

Subcutaneous Testosterone Injections are Easier

Subcutaneous injections make testosterone administration more convenient for patients

Increased studies showing the viability of subcutaneous hormone administration bring many possibilities for patients going through testosterone treatments.

Aside from providing a more balanced testosterone concentration and more level peaks and troughs, subcutaneous injections are generally seen as more convenient for the patient. As an alternative to intramuscular injections, subcutaneous administration provides a cheap and less painful means of administering hormones.

Because of this, more providers, scientists and companies are exploring options that employ subcutaneously administered testosterone.

Hormone Therapeutics provides you the right method for you

As men age, testosterone concentration decline, causing many symptoms of low testosterone and unsatisfactory changes or difficulties in their lives. However, thanks to increasing medical advancements, these hormonal deficiencies and issues are no longer problems men have to bear on their own.

With the increasing amount of alternatives for testosterone treatment nowadays, it is not difficult for men to find a treatment method that they are comfortable with. As a variety of hormone treatments to supplement endocrine systems are now being made available, men can now choose to improve their quality of life through treatment methods that are best suited for them.

Here at Hormone Therapeutics, we want to help you find the best alternative for you so you can live better. Focused on making sure that each client gets a convenient and affordable solution to their needs, we provide testosterone injections, along with various endocrine treatments in order to improve quality of life.  All our articles have been brought to you by SEO Advisors.

If you have any questions or inquiries regarding subcutaneous testosterone injections or other forms of testosterone or hormone therapy, Hormone Therapeutics will be glad to tell you more about our services and provide a physician evaluation of your options. Give us a call and we will help you learn more about testosterone and hormone therapy and find the best solution for you. 

Revealed: Subcutaneous Testosterone Injections Offer More Favorable Effects

Saleamp Design April 19th, 2016

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bloodletting for polycythemiaTherapeutic phlebotomy, colloquially known as bloodletting and used to manage red blood cell counts and Hematocrit levels, has a very long history in medical practice. The technique has been used for hundreds if not thousands of years across the globe.

The original logic behind bloodletting is simple but flawed. If disease lives within the blood, then removing the blood must also remove the disease. Of course, today we know that disease isn’t quite that simple. Modern medical practice discarded the technique as ineffective and dangerous.

Recent evidence, though, has brought therapeutic phlebotomy back in very specific cases. There are some medical conditions which can be treated or managed by the controlled removal of red blood cells and iron from the body, and the technique has found new life among today’s doctors.

Treatment of Polycythemia through Bloodletting

One such condition that responds to therapeutic phlebotomy is polycythemia. The word literally translates to “many blood”, and refers to an overproduction of red blood cells in the body. People suffering from polycythemia have blood that is thick, viscous, or “sticky”, and the condition can be fatal. Blood in this state is more difficult for the heart to handle, potentially leading to high blood pressure, heart attack, or stroke.

The disorder can be brought on by a number of factors.

Potential Causes of Polycythemia

  • Stress
  • Medications
  • Heavy smoking
  • Overabundance of testosterone
  • Dehydration
  • Obesity
  • Altitude

Testosterone and High Red Blood Cell Count – Polycythemia

The rise of testosterone replacement therapy has led to an increased instance of polycythemia. Testosterone treatments are wonderfully effective in a variety of cases, but like any medical treatment, it must be administered with care by a medical professional.

Testosterone, as well as assisting with mood support, building physical capability, and its other positive effects, stimulates the body to produce more red blood cells. Increased blood production is beneficial in some cases, such as in anemic patients, but can result in polycythemia if not carefully monitored.

Men are more prone to developing the condition, as they are usually prescribed much higher doses of testosterone than women.

Generally, the doctor administering testosterone therapy will manage the treatment to minimize the risk of side effects such as polycythemia. If red blood cell counts creep up too high, the excess blood can be drained away using the old technique of therapeutic phlebotomy, or bloodletting.

Removing a single pint of blood is usually enough to bring red blood cell counts back to normal. The blood can also be donated to a blood bank, if the patient’s blood is eligible.

Repeated bloodletting sessions are indicated in some cases if polycythemia recurs.

The effects of therapeutic phlebotomy are immediate, since they involve the physical removal of blood from the body. Symptoms such as high blood pressure subside instantly, and most patients report feeling better right away.

Testosterone and Hematocrit levels

Due to the instance of polycythemia in patients receiving testosterone replacement therapy, regular follow-up testing is extremely important even after the treatments are complete. Among other measurements, doctors will measure the Hematocrit and Hemoglobin in patients who have received testosterone treatments.

This measures the quantity of red blood cells in the body, or hematocrit, a component of the blood.  When this is too high, the blood becomes thicker or more viscus and if not managed properly could put more strain on the body.  Ensuring blood cell count and hematocrit levels remain within the normal range is important to anyone’s health, but especially so for recipients of testosterone therapy.

Medications are often used for long-term management of hematocrit levels, as well as therapeutic phlebotomy sessions if hematocrit rises too high.

Other Benefits of Therapeutic Phlebotomy

As well as effectively managing polycythemia, bloodletting is sometimes used as a treatment for hypertension, or high blood pressure. Removing a pint of blood has been shown to decrease blood pressure and “bad” cholesterol levels, during a study performed at Immanuel Hospital in Berlin.

The inspiration for the study was the finding that regular blood donors had a reduced instance of high cholesterol, as well as reduced risk of coronary disease and stroke.

The idea that removing blood from the body would reduce blood pressure seems obvious in retrospect. The technique is an ancient one, but still has merit today under controlled circumstances.

Different studies have also shown that therapeutic phlebotomy can aid diabetics in controlling blood sugar levels.

Finally, most patients report increased energy levels and feelings of health after bloodletting. Although this is not necessarily a reason to receive the treatment in and of itself, patients and doctors alike often consider it a nice bonus.

Do You Need Help?

Hormone Therapeutics is the leading national company assisting men who want to get their lives back through Hormone Replacement and Testosterone Replacement therapy. Our local physicians are ready to treat you anywhere in the entire country. Hormone Therapeutics is pioneering an easier, cost efficient and more private way for you to work with our clinical advisors and physicians from the privacy of your home or office after your local physical exam confirms you have one of the symptoms of Low T.

Contact us today and our clinical seo advisors will work with you on a hormone therapy program that may include prescribed hormones, exercise, nutrition and sleep programs to reclaim your vitality.

Here’s How Bloodletting Help Manage Polycythemia and Hematocrit levels Caused by Testosterone Replacement

Saleamp Design April 15th, 2016

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testosteroneA study has shown that serum testosterone concentration in men may have links to fitness and health levels that can serve as an indicator of general health. These studies are exploring how testosterone content may affect all-cause mortality in older men and what it may mean for men as they age.

Testosterone Concentration in Men

Testosterone (T) is a hormone produced by males in the testicles after a communication pathway called the HPA axis from the hypothalamus to the pituitary gland through the adrenals and to the gonads. While it is also present by women, it is produced in much higher concentrations in men. It is responsible for maintaining energy, bone density, muscles mass, sperm production and sex drive, along with other traits, and is associated with maintaining many of the characteristics associated with men. 

The level of T concentration in men peaks and declines at given points in their lifetime. In general, serum T concentration is highest in adolescence and young adulthood, when it is at its peak. However, as men age, its levels commonly undergo a steady decline. Men peak at age and experience a range of one to two percent decline in their  concentration.

Testosterone levels and their links to health

Scientists have been exploring possible links of testosterone as an indicator of men’s health conditions, studying the correlation of low T with general health and mortality.

One study has discovered that while a decline in men’s T levels of one to two percent is considered normal, a sudden and immediate drop in testosterone concentration may be associated with an increased probability of mortality. Based on observations, a low level of serum testosterone concentration in men is seen as associated with risk factors such as diabetes and cardiovascular problems. However, while these conditions may be associated with illnesses and premature death, the FDA is not saying they see a direct causational effect between decreasing testosterone and longevity.

Scientific Testosterone Studies

Currently, available studies tackling the topic have produced mixed results. In one study researching a sample of 794 men, it was concluded that men whose testosterone levels were in the lowest quartile of test subjects were at a 40% greater risk of mortality in comparison to those men who had higher levels. A 15 year study of US military veterans also showed that men with low T levels, treated under physician guidance and supplemented back to normal levels above 500, had lower incidence of heart attack, stroke, prostate cancer and death.

In an effort to consolidate all the data and results from these previous researches, a newer study examined multiple works from 1966 to 2010 in order to gain a clearer and more definitive understanding of testosterone levels and mortality. In addition to testosterone levels, it also took into account lifestyle factors, age and other characteristics that may affect results.

Low Testosterone and Higher Mortality or Cardiovascular Risk

Ultimately, the research concluded that a decline in total testosterone was linked with cardiovascular mortality by 25% and with higher susceptibility to general, all-cause mortality by 35%.

The study did note that other factors may influence the relative risk that was determined in the study. Among these, researchers noted the age of the population studied, the total testosterone level and the amount of years the patient followed up as possible sources of differences within the study. The study also observed the most susceptible demographics for larger relative risks. These included patients with lower levels of testosterone, older men and patients who followed up for a smaller amount of years.

As a conclusion, the data gathered from this research establishes low T as a possible basis or indicator of general health in men. However, while it may be seen as a marker of higher susceptibility to all-cause mortality, it is not strictly a direct source of it. Overall, there remains much to be learned about the two.

Hormone Therapeutics

Aside from being and indicator of one’s general well-being, testosterone levels and hormone balance are traits that can greatly affect one’s quality of life. As men age, it becomes important to monitor these factors in order to gain a better idea of one’s health and fitness.

Hormone Therapeutics specializes in assisting people with endocrine-related concerns in order to help them monitor and regulate the level of hormones in their bodies. If you have any inquiries regarding your testosterone level and what it means for you, Hormone Therapeutics can help you jumpstart your life and provide you with the answers you need.

Testosterone Levels’ Link to General Health in Men

Saleamp Design April 12th, 2016

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erectile dysfunctionErectile dysfunction is a common problem that affects many men. This being said, it is important to explore its causes and how it can be addressed. Because of testosterone’s prominence in men’s sexual function, it has been explored as a determining factor in erectile dysfunction. The following study describes how erectile dysfunction and low libido may be related to available testosterone in the body.  It also examines how supplementing this testosterone deficiency may provide a better for you.

 Different Types of Testosterone for Erectile Dysfunction   

Many do not know that there are different types of testosterone in the body and that it is important to take note of their individual levels within a person’s system. The testosterone level measured when men go to the doctor is typically limited only to Total Testosterone.  Patients only get the sum of unbound and bound testosterone present in the patient’s system.

The problem with this that the total amount of testosterone measured is not always fully available for use. Because of the presence of bound and unbound testosterone in the system, the Total Testosterone measurement for a person may not equal the precise amount of testosterone he is actually able to utilize.  This is called Free Testosterone.

This is because bound and unbound testosterone are indicators of whether or not a testosterone can be immediately used by the body this Free Testosterone is a more important measure. A bound testosterone is one attached to proteins that need prior removal before it can be used, thereby needing some effort to be utilized. One of the proteins that binds to testosterones is albumin. While albumin does attach to testosterones, it is easily removed by the body when the testosterone is needed.

However, there are also particularly stubborn binding proteins that cannot be removed from the testosterone, thus rendering it unusable. An example of this is the Sex hormone binding globulin, or SBHG. Once SBHG attaches to your testosterone, it becomes unusable due to the difficulty of separating the protein from the testosterone, limiting the amount of available testosterone in the body.

The differences in functions and availability of these kinds of testosterone highlight the need to test for different types of testosterone. In studying testosterone levels in the system, it’s important to take into account the level of total testosterone, bio-available testosterone and free testosterone, along with the prevalence of SBHG proteins in the patients.

Free testosterone refers to unbound testosterones which are readily available to the body and thus, can be used with minimal effort. Bio-available testosterone, on the other hand, corresponds to both the free testosterones and testosterones bound to easily removed proteins such as albumin. SBHG limits the amount of Bio-available testosterone, giving a skewed amount of usable testosterone when analyzing the total count.

Erectile dysfunction’s relationship to your testosterone levels

Because of testosterone’s role as a primary sex hormone that establishes male traits and sex drive, research has been made to explore how testosterone levels and erectile function influence each other.

According to the study, there exists a proportional correlation between testosterone levels and erectile function, linking higher levels of the hormone with an increased sex drive and better erections. In addition to this, it also established that low testosterone levels was consistently present in cases of erectile dysfunction, and that low presence of the hormone may hamper erectile dysfunction medications such as Viagra from working properly.

Ultimately, the study concluded that a low amount of free testosterone coupled with high levels of SHBG posed the highest risk for erectile dysfunction in men, emphasizing the importance of monitoring testosterone levels when addressing the problem. Taking from the study, it goes that while there are many factors that can contribute to erectile function, it is useful to check testosterone levels because it was seen as a consistent influencing factor for erectile dysfunction as based on the data.

Because of testosterone’s effect on erectile dysfunction, aging men who are experiencing its symptoms are advised to first take a testosterone blood test that can measure the amount of total testosterone, free-testosterone and SHBG in their system. Because ultimately, it is free testosterone that determines the ready supply of the hormone in men, testing total testosterone may not provide sufficient information regarding one’s actual hormone levels. By testing all levels of testosterone, doctors may be able to determine if it is this deficit in available testosterone that hampers proper erectile function and sexual performance, providing the patient with better options of addressing the problem.

Hormone Therapeutics can help you learn more about testosterone

With the emergence of treatments for low testosterone levels today, you don’t have to bear its consequences anymore.  This is why we have so many wives reaching out to us as well to find help for their loved one.  Hormone Therapeutics can help you determine if low testosterone that is causing your sexual problems and provide testosterone replacement therapy, to remedy your concerns. We can treat with testosterone therapy, and/or erectile dysfunction treatments. 

If you want to learn more about how to monitor your testosterone levels or fix low testosterone concentration and its consequences, our company can help you clear up your reservations. Give us a call and we’ll be happy to assist you as you take your first step towards improving your quality of life.

Linking Erectile Dysfunction and Low Testosterone

Saleamp Design April 5th, 2016

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DHEADehydroepiandrosterone (DHEA) is a naturally occurring hormone produced in the body. Secreted by the adrenal glands, it is precursor to other hormones and is transformed by the body into specific hormones once it reaches the target tissue. As a prohormone, most of it effects are related to its end products as opposed to DHEA itself. 

DHEA is gaining traction as an anti-aging supplement. It is also being explored as a treatment for several of the health conditions associated with aging. 

DHEA and its effects

DHEA is often touted as a “youth restoring” hormone because of its reputation for slowing down the age process, improving general energy levels and cognitive skills.  Because of this, many see it as a solution to regulate the side effects of aging and hormone depletion.

DHEA supplementation has shown an increase in energy, cognitive concentration, greater muscle mass/retention and slowing down the progression of Alzheimer disease. DHEA has been shown to have an influence on erectile dysfunction and lack of sex drive. In addition, Men with low DHEA more often experience depression as well as higher risks for overall mortality, including heart failure and cardiovascular threats.

DHEA Decline with Age

Unfortunately, DHEA production declines as its importance increases. DHEA production reaches its highest point during the 20s, but as one grows older, the body’s DHEA production  decreases, leaving as little as 20% of the healthy output by the time one reaches 70.

Since it is a precursor to other hormones, this decline leads to a corresponding effect in other hormones as well. Estrogen and testosterone synthesis, in particular, wane once the DHEA levels decrease. This brings forth several consequences for both sexes. In men, specifically, age-related DHEA decrease leads to a decline in testosterone secretion. This decline is compounded because of the larger role DHEA plays in the production of testosterone as we age.

DHEA Supplements and their Effects

From trials, DHEA supplements have been shown to increase muscle mass, strength and physical well-being in general. In addition, tests of increased concentration, in men and women, have been shown to improve sexual potency and mood, with women experiencing less menopausal symptoms after taking supplements. Overall, DHEA has been seen as an anti-aging supplement, providing bone and muscle strength, better moods and immune system and increased memory. 

When tested on patients with diabetes and neurological disorders, DHEA was not seen to improve erectile function and potency in patients. It has also been shown to exhibit minimal side effects such as mild acne, swollen ankles and increased facial hair in some women.

The effect of long term treatment on cardiovascular conditions and hormone-dependent tumors has not yet been studied, or have yielded conclusive results. 

DHEA Frontiers

DHEA supplements for anti-aging purposes are currently gaining traction. As a precursory hormone, it is seen by many as a way to regulate hormone balance within the body. In addition, DHEA’s reputation in increased bone and muscle strength, as well as energy, has many physicians exploring DHEA supplements and its effect on bone growth, depression, and other mood and cognitive disorders.

Hormone Therapeutics

Hormone Therapeutics specializes in endocrine and hormone-related treatment, and is committed to finding the best treatment for your well-being.  If you’re curious about how DHEA supplements can improve you and your life, Hormone Therapeutics can provide the answers for you. Call us today!

Do You Need Help?

Hormone Therapeutics is the leading national company assisting men who want to get their lives back through Hormone Replacement and Testosterone Replacement therapy. Our local physicians are ready to treat you anywhere in the entire country. Hormone Therapeutics is pioneering an easier, cost efficient and more private way for you to work with our clinical advisors and physicians from the privacy of your home or office after your local physical exam confirms you have one of the symptoms of Low T.

Contact us today and our clinical advisors will work with you on a hormone therapy program that may include prescribed hormones, exercise, nutrition and sleep programs to reclaim your vitality.

 

 

DHEA Benefits and Frontiers

Saleamp Design April 1st, 2016

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Depression from Low Testosterone and EstrogenA recent study at the George Washington University, found that men diagnosed with borderline low testosterone levels had much higher rates of experiencing depression and depressive symptoms compared to the general population. In the study, 56% of the male participants were diagnosed with depression while 25% were already taking medications for this.

Produced in the testicles, testosterone helps drive a man’s production of sperm, muscle strength and mass, sex drive, facial and body hair and bone density.  Men who don’t produce the normal amount of testosterone may have a condition called hypogonadism.

To Ward off Depression, Testosterone Converts to Estrogen

Testosterone, the male sex hormone, seems to have anti-depressant like properties, yet the exact mechanism of its effect still remained unclear.

In 2012, Mohammed Kabbaj and Nicole Carrier, both researchers at the Florida State University College of Medicine, are working to elucidate such mechanisms.  They have found out that a particular pathway called MAPK pathway in the hippocampal region, a part of the brain, involved in regulation of stress responses and memory formation, plays a vital role in mediating the effect of testosterone.

Low Testosterone and Depression

Between men and women, females are typically more prone to suffer from depression, however, men diagnosed with low T or hypogonadism are also predisposed to depression or anxiety. Fortunately, hormone replacement therapy has been found to effectively enhance mood.

While it may seem that much is already known, it’s still very important to fully understand where and how these effects are happening so that scientists can develop better, targeted antidepressant therapies.

In the study, Kabbaj performed several experiments in neutered male rats and found that the rats manifested depressive-like behaviors that were then reversed by supplemental testosterone replacement.

According to the researcher, in order to protect males with hypogonadism from developing depression, testosterone in the brain must be converted to estrogen. Kabbaj stated a certain brain enzyme ‘mediates’ the conversion of testosterone to estrogen. Furthermore, inhibiting such enzyme in the hippocampal area has prevented the antidepressant effect of testosterone.  This makes the conversion to estrogen vital.

In this study, the antidepressant effect of supplementing low testosterone to normal levels has only manifested in male rats, not in female rats.

 

Do You Need Help?

Hormone Therapeutics is the leading national company assisting men who want to get their lives back through Hormone Replacement and Testosterone Replacement therapy. Our local physicians are ready to treat you anywhere in the entire country. Hormone Therapeutics is pioneering an easier, cost efficient and more private way for you to work with our clinical advisors and physicians from the privacy of your home or office after your local physical exam confirms you have one of the symptoms of Low T.

Contact us today and our clinical advisors will work with you on a hormone therapy program that may include prescribed hormones, exercise, nutrition and sleep programs to reclaim your vitality.

 

Revealed: How Testosterone Converts to Estrogen to Battle Depression

Saleamp Design March 29th, 2016

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What is testosterone replacement therapy? How does Estrogen effect my testosterone levels or how I feel?  What is Estradiol or E2 and what do I need to know about estradiol monitoring?  Why is it important to monitor estrogen level before getting TRT? What if my estrogen level is elevated, should I still be treated or not? What are the downsides of TRT? Is it dangerous?

These are some of the most common questions most men ask during testosterone replacement therapy. Read below to know more about this treatment.

What is Testosterone Replacement Therapy?

Testosterone Replacement therapy

Testosterone replacement therapy (TRT) is a medical treatment that aims to restore hormone levels back to a normal range without any significant side effects or safety concerns. More importantly, it should alleviate the symptoms associated with the hormone deficiency.

The ultimate goal of TRT is to regain and maintain the highest quality of life, compress major illnesses and reduce disability; and add life to years.

Estradiol Monitoring: Why is it important to monitor estrogen level before getting Testosterone Replacement Therapy?

As a Man’s testosterone level decreases, typically his estrogen levels are increasing.  Testosterone replacement therapy can also lead to elevations in estrogen level in some men who convert a portion of their testosterone supplementation to Estradiol. In some cases, the level could be above the normal range. While TRT is not about jacking up a man’s testosterone, it should also not be about suppressing his Estrogen or Estradiol/E2.

When the estrogen levels increase, a person may develop breast or nipple tenderness (gynecomastia), which may call for the use of aromatase inhibitors (AIs) – a potent estradiol-suppressor that is primarily used as an adjuvant treatment for breast cancer by lowering estrogen and thereby reducing the stimulation of estrogen receptors in such disease. 

Some doctors prefer stopping TRT first when symptoms of high estrogen levels are becoming apparent rather than managing it through AIs.  Many doctors, and Broscience websites, promote the absolute use of aromatase inhibitors during TRT despite the absence of symptoms or signs of increase estrogen or Estradiol. They believe that keeping a relatively low estrogen concentrations can boost the effectiveness of TRT and improve male health.  This approach, however, can cause other problems.

We at Hormone Therapeutics follows medical protocols and believe in treating the symptoms and the blood tests.  The Total Testosterone:Estradiol ratio needs to be kept below 5%.  We believe in monitoring and maintaining this level.

What if my estrogen level is elevated, should I still be treated or not?

Estrogen levels in some men administered with aromatase inhibitors have levels that sink below 40pmol/L, which may pose increased risk on bone health, energy and emotional health.

Perhaps the only study that can compare the use of TRT with and without anastrazole were in men diagnosed with hypogonadism, hyposexuality and epilepsy. The first trial revealed a positive effect on the sexual interest with the addition of testolactone therapy.

On the second trial that involves men reported an increase in libido among men treated with anastrazole and testosterone alone. However, this trial didn’t attain statistical significance because some men from the T-alone group also reported increase in sexual interest despite an increase in their estrogen.

However, these studies must be taken with caution because it isn’t clear how the group compares with the bigger group with low-T. This group were also treated with antiseizure drugs which increases SHBG (Sex hormone-binding globulin) – a glycoprotein that attaches to the two sex hormones, estrogen and androgen.

Therefore, there is no solid evidence to support the claim that the use of aromatase inhibitor in conjunction with TRT provides benefits more than that provided by TRT alone.

Do You Need Help?

Hormone Therapeutics is the leading national company assisting men who want to get their lives back through Hormone Replacement and Testosterone Replacement therapy. Our local physicians are ready to treat you anywhere in the entire country. Hormone Therapeutics is pioneering an easier, cost efficient and more private way for you to work with our clinical advisors and physicians from the privacy of your home or office after your local physical exam confirms you have one of the symptoms of Low T.

Contact us today and our clinical advisors will work with you on a hormone therapy program that may include prescribed hormones, exercise, nutrition and sleep programs to reclaim your vitality.

Estrogen Monitoring – Estradiol Must Be Monitored During Testosterone Replacement Therapy

Saleamp Design March 22nd, 2016

Posted In: Testosterone Therapy

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Hormone Therapeutics created a national telemedicine platform to bring world class Testosterone and Hormone Replacement Therapy physicians right to your home.  Get an expert specialist physician to provide testosterone telemedicine guidance at home.  Telemedicine testosterone therapy allows us to help patients wherever they live as we have designed a separate program for each state to work with our locally licensed physicians and pass all of the national and state wide regulations of which there are a lot.

Telemedicine Testosterone Therapy

Here, Hunter Howard discusses his history in healthcare as well as the increase of telemedicine access in the evolving US healthcare system.  The key is how Hormone Therapeutics reduces weekly office visits for shots but maintains the same high standard of care and even increases it in many cases.  Telemedicine testosterone therapy allows patients to reach our specialist from home, set up local blood tests, schedule a local physical exam and start on a program where the treatments are mailed directly to the patient and consultations are available anytime the patient needs guidance.  We are available anywhere and anytime. 

Listen to the Podcast

Learn more about our innovative approach to delivering patient care.  We discuss this in the 20 minute podcast link below.  We also discuss the development of digital health and virtual visits to help healthcare catch up with the the evolution so many other industries have experienced.  The benefit goes to the consumer with patient-centric care.  This is what drove our vision to help improve the lives of patients anywhere.  These patients are paying too much to anti-aging specialists in vanity palace facilities in cities like Miami, LA and Dallas.  We are even more excited to bring a solution to cities like Topeka and Springfield. In these cities the only possible solution is going to a primary care physician, who is rarely trained in hormone optimization.  Thees physicians can only prescribe the low dose, one size fits all Androgel or Axiron.  These low does gels are rarely effective for most patients.  We are excited to help men live healthier and more productive lives.  Our solution is lower cost, easier, more convenient and more private solution

Listen to Podcast

Telemedicine testosterone therapy guidance

Saleamp Design January 15th, 2016

Posted In: Low T Info, Telemedicine, Testosterone Therapy

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